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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...

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Related Experiment Video

Updated: May 20, 2026

Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography
06:31

Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography

Published on: October 6, 2023

Charcot arthropathy presenting with primary bone resorption.

Christopher W Jones1, David Agolley, Kharis Burns

  • 1Department of Orthopaedic Surgery, Royal Prince Alfred Hospital, Sydney, Australia. cjon0040@gmail.com

Foot (Edinburgh, Scotland)
|July 28, 2012
PubMed
Summary
This summary is machine-generated.

Diabetic Charcot arthropathy can present with rapid bone resorption without fractures or dislocations. Early MRI is recommended to detect this aggressive bone resorption process.

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Last Updated: May 20, 2026

Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography
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Published on: October 6, 2023

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
07:03

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

Published on: June 16, 2022

Area of Science:

  • Diabetology
  • Orthopedics
  • Rheumatology

Background:

  • Diabetic Charcot arthropathy typically follows the Eichenholtz classification.
  • Acute Charcot arthropathy in diabetic patients usually presents with subluxation, dislocation, or fracture.

Observation:

  • This study reports three cases of Charcot arthropathy with rapid primary bone resorption.
  • These cases lacked the typical signs of subluxation, dislocation, and fracture.

Findings:

  • Primary bone resorption, previously undescribed in Charcot arthropathy, presents a diagnostic challenge, often mistaken for infection.
  • The pathophysiology may involve an imbalance between RANK-L and OPG, leading to increased osteoclastic activity and osteolysis.
  • Aggressive primary bone resorption can indicate an active Charcot process.

Implications:

  • Early diagnosis and treatment are crucial for managing this aggressive form of Charcot arthropathy.
  • Serial radiography and early MRI are recommended to identify widespread bone and soft tissue edema.
  • Understanding this presentation aids in differentiating it from infection, improving patient outcomes.