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Related Experiment Video

Updated: May 20, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
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Titanium phosphate glass microspheres for bone tissue engineering.

Nilay J Lakhkar1, Jeong-Hui Park, Nicola J Mordan

  • 1Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK.

Acta Biomaterialia
|July 28, 2012
PubMed
Summary

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We developed inexpensive titanium phosphate glass microspheres for bone tissue engineering. The 5 mol.% TiO₂ composition showed optimal structural integrity and biocompatibility for cell growth.

Area of Science:

  • Biomaterials Science
  • Materials Engineering
  • Biotechnology

Background:

  • Bone tissue engineering requires suitable scaffold materials.
  • Titanium phosphate glasses offer potential due to their biocompatibility.
  • Developing scalable and cost-effective production methods is crucial.

Purpose of the Study:

  • To synthesize and characterize titanium phosphate glass microspheres.
  • To evaluate their suitability for bone tissue engineering applications.
  • To determine the optimal TiO₂ content for material properties and cell response.

Main Methods:

  • Melt-quench technique to prepare glasses with varying TiO₂ content (3, 5, 7 mol.%).
  • Differential thermal analysis, degradation studies (time-lapse imaging), pH, and ion release measurements.

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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

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  • MG63 cell culture for 7 days to assess biocompatibility and proliferation.

    • Main Results:

    • Glass microsphere production was successful in the 10-200 μm range.
    • Increased TiO₂ content up to 5 mol.% enhanced glass structural densification.
    • Microspheres supported MG63 cell attachment, growth, and proliferation effectively.

    Conclusions:

    • Titanium phosphate glass microspheres are readily produced using a scalable method.
    • 5 mol.% TiO₂ composition demonstrates favorable structural and biocompatibility properties.
    • These microspheres are promising substrate materials for bone tissue engineering.