Peptic ulcer disease in youths with insulin-dependent diabetes mellitus: a prospective study

Tested whether metabolic control, treatment variables, and psychosocial factors are associated with the onset of peptic ulcer disease (PUD) in 14 Ss with IDDM who later developed PUD and a matched group of 14 Ss who did not. Metabolic control was recorded 1 year before PUD diagnosis, at diagnosis, and 6 and 12 months after diagnosis. Treatment variables (adherence, insulin dose, number of injections, number of hospitalizations) and psychosocial factors (coping, stress, family relations) were assessed an average of 20 months prior to PUD diagnosis. A 2 (Group) x 4 (Time) repeated measures ANOVA revealed no between-groups differences on metabolic control. One-way ANOVAs indicated the groups did not differ on treatment variables or psychosocial factors, except that Ss in the PUD group reported more insulin injections. Research is needed regarding the correlates of PUD in Ss with well-controlled IDDM of relatively brief duration.