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Updated: May 20, 2026
Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Pituitary stalk Langerhans cell histiocytosis treated with CyberKnife radiosurgery
Wei-Chen Hong1, Judith A Murovic, Iris Gibbs
1Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Objective:
Langerhans cell histiocytosis (LCH) is a rare idiopathic disease that is characterized by clonal proliferation of Langerhans histiocytes in various parts of the body. These atypical cells have been found to infiltrate single or multiple organs, including bone, lungs, liver, spleen, lymph nodes, and skin. Central nervous system invasion in LCH patients has rarely been reported, especially in the adult population.
Methods And Results:
We describe three histopathologically confirmed cases of adult LCH that involves both the pituitary stalk and hypothalamus, and report our limited experience of such cases in this location that has been treated with CyberKnife radio surgery.
Conclusion:
The treatment goal of controlling lesion growth is achieved by CyberKnife radiosurgery in this case series. All patients tolerated the treatment well without obvious complications.
