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Updated: May 20, 2026

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Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
Published on: February 27, 2016
Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2
Ubaldina Galli1, Ornella Mesenzani, Camilla Coppo
1Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale A. Avogadro, Largo Donegani 2, 28100 Novara, Italy.
European Journal of Medicinal Chemistry
|July 28, 2012
Abstract:
As part of an effort to identify novel selective modulators of sirtuins, we synthesized and tested several isosteres and constrained analogues of nicotinamide. Biological data suggest that compound 2 is selective for Sirt3 over Sirt1 and Sirt2.
