Related Experiment Video

Updated: May 20, 2026

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
08:11

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

Published on: September 1, 2015

Cryptoccocal meningitis and HIV in the era of HAART in Côte d'Ivoire

E F Aoussi1, E Ehui, J P Dembélé

  • 1Service des maladies infectieuses et tropicales, CHU de Treichville, 01 BP V3, Abidjan 01, Côte d'Ivoire. ebaaoussi@hotmail.com

Medecine Et Maladies Infectieuses
|July 28, 2012
PubMed

Insights

Cryptococcal meningitis is common in HIV-infected adults in Ivory Coast, with a high mortality rate. Early management of cryptococcal meningitis is crucial for improving patient outcomes.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Public Health

Background:

  • Cryptococcal meningitis is a significant opportunistic infection in individuals with Human Immunodeficiency Virus (HIV).
  • Management strategies and outcomes for cryptococcal meningitis in resource-limited settings require further elucidation.

Purpose of the Study:

  • To describe the clinical management and outcomes of cryptococcal meningitis among HIV-infected adults in Ivory Coast.

Main Methods:

  • A retrospective study analyzed data from 80 hospitalized patients with cryptococcal meningitis between 2005 and 2008.
  • Data collected included socio-demographic, clinical, and biological characteristics, treatment regimens, and patient outcomes.

Main Results:

  • The study included 80 patients (51.25% male, mean age 40 years) with cryptococcal meningitis, representing 2.6% of hospitalizations.
  • Common symptoms included headache (83.7%), fever (63.7%), and altered consciousness (60%). 67.5% were not on antiretroviral therapy (ART) with low CD4 counts.
  • The mortality rate was high at 41.2%, despite treatment with Amphotericin B and fluconazole in most cases.

Conclusions:

  • Cryptococcal meningitis remains a frequent and often fatal complication in HIV-infected adults in Ivory Coast, even with ART availability.
  • The high mortality rate underscores the critical need for prompt diagnosis and effective management strategies to improve prognosis.
Abstract

More Related Videos

An In vitro Co-infection Model to Study Plasmodium falciparum-HIV-1 Interactions in Human Primary Monocyte-derived Immune Cells07:39

An In vitro Co-infection Model to Study Plasmodium falciparum-HIV-1 Interactions in Human Primary Monocyte-derived Immune Cells

Published on: August 15, 2012

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection08:14

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

Published on: October 6, 2015

Related Concept Videos

Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...