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Updated: May 20, 2026

Bacteriophage Removal from Infected Salmonella Cultures
Published on: June 28, 2024
Does phage P22 contribute to resistance of Salmonella to oxidative stress?
Tomáš Szemes1, Barbora Vlková, Gabriel Minárik
1Department of Molecular Biology, Comenius University, Bratislava, Slovakia.
Abstract:
Resistance to oxidative stress belongs to key virulence factors of bacterial pathogens including Salmonella. Typing of prophages in the genome is used to identify individual Salmonella strains. Some of the prophages and prophage remnants contain genes coding for important and metabolically active enzymes. We hypothesize that antioxidative status of the host Salmonella is affected by the bactoprenol glucosyltransferase (gtrB) from the P22 phage and that this effect is mediated by enhanced production of antioxidative selenoproteins. Our hypothesis is testable using targeted bacterial mutants exposed to oxidative stress in vivo and in vitro.
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