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Updated: May 20, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report
Takahiro Nunokawa1, Masanobu Akazawa, Naoto Yokogawa
11Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Fuchu-shi, Tokyo, Japan; 2Department of Nephrology, Tokyo Kyosai Hospital, Meguro-ku, Tokyo, Japan; 3Hiramatsu Naika Clinic, Kokubunji, Tokyo, Japan; and 4Department of Nephrology, Tokyo Metropolitan Tama Medical Center, Fuchu-shi, Tokyo, Japan.
Abstract:
Scleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc.
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