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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Related Experiment Video

Updated: May 20, 2026

Whole-cell MALDI-TOF Mass Spectrometry is an Accurate and Rapid Method to Analyze Different Modes of Macrophage Activation
11:25

Whole-cell MALDI-TOF Mass Spectrometry is an Accurate and Rapid Method to Analyze Different Modes of Macrophage Activation

Published on: December 26, 2013

[Macrophage activation syndrome].

P Lehmann1, E Huber, T Dörner

  • 1Klinik und Poliklinik für Rheumatologie/Klinische Immunologie, Asklepios Klinik Bad Abbach, Kaiser-Karl V.-Allee 3, 93077, Bad Abbach, Deutschland. pe.lehmann@asklepios.com

Zeitschrift Fur Rheumatologie
|July 28, 2012
PubMed
Summary
This summary is machine-generated.

Macrophage activation syndrome (MAS) is a severe autoimmune complication with sepsis-like symptoms. Early diagnosis and treatment are crucial for better patient outcomes.

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Last Updated: May 20, 2026

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Area of Science:

  • Immunology
  • Rheumatology
  • Pathophysiology

Context:

  • Macrophage activation syndrome (MAS) is a rare but life-threatening condition.
  • It is associated with various autoimmune diseases, indicating immune system dysfunction.
  • The exact underlying abnormalities driving MAS require further elucidation.

Purpose:

  • To highlight the diagnostic challenges of MAS.
  • To emphasize the critical need for early diagnosis and intervention.
  • To outline current and emerging therapeutic strategies for MAS.

Summary:

  • MAS involves excessive macrophage activation, leading to symptoms like cytopenia, hepatosplenomegaly, coagulopathy, and organ dysfunction.
  • Diagnosis is difficult due to the absence of validated criteria and specific biomarkers.
  • Prompt treatment, including glucocorticoids, immunosuppressants, and biologics, is vital.

Impact:

  • Improved understanding of MAS pathophysiology.
  • Enhanced diagnostic approaches for clinicians.
  • Optimized patient management and therapeutic interventions for MAS.