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Information about medication in HIV-infected patients and its relation to adherence
Virginie Korb-Savoldelli1, Florence Gillaizeau, Thibaut Caruba
1Pharmacy Department, AP-HP Georges Pompidou European Hospital, Paris, France. virginie.savoldelli@gmail.com
Insights
HIV patients
Area of Science:
- Pharmacology
- Public Health
- Infectious Diseases
Background:
- Medication adherence is crucial for Highly Active Antiretroviral Therapy (HAART) effectiveness in HIV patients.
- Understanding information sources is key to improving patient adherence.
Purpose of the Study:
- To identify information sources used by HIV patients for HAART.
- To assess the impact of these sources on medication adherence.
- To determine profiles of non-adherent patients and the pharmacist's role.
Main Methods:
- Cross-sectional, observational study conducted in community and hospital pharmacies.
- Data collected via self-reported questionnaires from 233 HIV-infected patients.
- Analysis included multivariate regression to identify factors associated with adherence.
Main Results:
- Physicians (hospital and community) and patient leaflets were the most common information sources.
- Only 16.3% and 3.4% of patients consulted community and hospital pharmacists, respectively.
- Adherence was associated with information from physicians, the internet, and patient associations.
Conclusions:
- Physicians are the primary and most helpful information source for HIV patients regarding HAART.
- The pharmacist's role in providing HAART information is underutilized.
- Enhanced communication between pharmacists and outpatients is needed to improve adherence.
Questions Under Study:
In HIV-infected patients, comprehension of medication instructions is an essential condition for adherence to Highly Active Antiretroviral Therapy (HAART). In this study, we used a self-reported questionnaire to know which sources of medication information HIV-infected patients used and their impact on adherence. In secondary objectives, we determined profiles of non-adherent patients and specified the role of the pharmacist.
Methods:
A cross-sectional, observational study was conducted in one community pharmacy and one French university hospital pharmacy, in HAART-naïve or not patients, from April to June 2009.
Results:
During the 3-month study period, 233 HIV-infected patients were included. The majority of patients sought information about their HAART treatments from the hospital physician (79.8%), the community physician (74.2%), and patient information leaflets (73.8%). The community and hospital pharmacists were consulted by respectively 16.3% and 3.4% of patients. According to multivariate regression analysis, adherence seemed to be associated with the sources of information "community physician", "hospital physician", "internet", and the potential support of patient associations. A total of 65.7% of patients were considered to be adherent.
Conclusions:
In our study, among sources used by HIV-infected outpatients, their physicians are the most helpful sources of information about HAART. Regarding practice implications, the key role of the pharmacist is underutilised, indicating the need for improved communication between the pharmacist and outpatients.
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