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[Clinical evaluation of cefuzonam of severe infections in leukemia and related disorders]
S Tsuda1, S Tanaka, H Nakagawa
1Third Department of Internal Medicine, Kyoto Prefectural University of Medicine.
Abstract:
Cefuzonam (CZON) which has a broad spectrum on both Gram-negative and Gram-positive bacteria including methicillin-resistant Staphylococcus aureus was evaluated in severe infections associated with hematological disorders. Sixty five patients were treated with CZON. Among them, 56 patients were evaluable for effectiveness. Nine patients were not evaluable because 3 patients were treated with combination of other antibiotics such as ceftizoxime, norfloxacin, ofloxacin, 1 patient was subjected to additional therapy of G-CSF and gamma-globulin, 4 were the patients with other disease than hematologic disorder (3 malignant mesotheliomas, 1 ovarian cancer), and the remaining one was prophylactically treated. Excellent responses were observed in 21 (37.5%) patients, good responses in 11 (19.6%) patients, with an overall efficacy rate of 57.1%. The efficacy rate in septic patients was 80% (4/5), and that in patient whose peripheral granulocytes were continuously below 100/microliters was 60% (3/5). Three patients who suffered from malignant mesothelioma, one patient who suffered from ovarian cancer, one patient who was treated prophylactically were included in the final evaluation of side effects. Side effects were observed in 2 patients (2/61, 3.3%). In a patient of 7 years, mild liver disfunction (GOT/GPT, 46/55) was found in 10 days after CZON treatment was started. In a patient of 65 years, mild appetite loss was identified in 2 days after CZON administration was begun. The liver disfunction was improved soon after the cessation of the treatment. The mild appetite loss disappeared while the treatment was continued. These results showed that CZON was an effective and safe antibiotic for the treatment of severe infections in patients with hematological disorders.
Insights
Cefuzonam (CZON) effectively treated severe infections in patients with hematological disorders, showing a 57.1% efficacy rate. This broad-spectrum antibiotic demonstrated safety with minimal side effects in the evaluated patient cohort.
Area of Science:
- Infectious Diseases
- Hematology
- Pharmacology
Background:
- Severe infections pose significant risks for patients with hematological disorders.
- Broad-spectrum antibiotics are crucial for managing these complex infections.
- Methicillin-resistant Staphylococcus aureus (MRSA) presents a particular challenge.
Purpose of the Study:
- To evaluate the efficacy and safety of Cefuzonam (CZON) in treating severe infections in patients with hematological disorders.
- To assess CZON's effectiveness against Gram-negative and Gram-positive bacteria, including MRSA.
Main Methods:
- A clinical study involving 65 patients with hematological disorders and severe infections.
- Treatment with Cefuzonam (CZON).
- Evaluation of treatment effectiveness and side effects in 56 evaluable patients.
Main Results:
- An overall efficacy rate of 57.1% was observed in 56 evaluable patients.
- Excellent and good responses were seen in 37.5% and 19.6% of patients, respectively.
- A low incidence of side effects (3.3%) was reported, including mild liver dysfunction and appetite loss.
Conclusions:
- Cefuzonam (CZON) is an effective and safe antibiotic option for severe infections in patients with hematological disorders.
- The drug demonstrated a favorable safety profile with manageable adverse events.
- Further research may explore CZON's role in specific hematological conditions and resistant bacterial infections.