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Cutaneous manifestations of internal malignancy.
A Ayyamperumal1, Gk Tharini, Vidhya Ravindran
1Department of Dermatology, Madras Medical College, Government General Hospital, Chennai, India.
Indian Journal of Dermatology
|July 28, 2012
Summary
Skin changes occur in nearly 7% of internal malignancy patients. Cutaneous metastases were found in 2.66%, while nonspecific lesions appeared in 4.26%, highlighting the importance of dermatological assessment in oncology.
Area of Science:
- Oncology
- Dermatology
- Internal Medicine
Background:
- Internal organ malignancies frequently present with skin manifestations.
- These cutaneous changes can be specific (tumor metastases) or nonspecific lesions.
Purpose of the Study:
- To determine the frequency and significance of skin changes in patients with internal malignancy.
- To analyze the types and prevalence of specific and nonspecific cutaneous lesions.
Main Methods:
- A study of 750 patients with confirmed internal malignancy at a South Indian cancer chemotherapy center.
- Histopathology, fine needle aspiration cytology (FNAC), and marker studies were used to confirm specific infiltrates.
Main Results:
- Skin changes were observed in 52 (6.93%) of the 750 patients.
- Cutaneous metastases (specific lesions) were present in 20 patients (2.66%), with 6 contiguous and 14 non-contiguous.
- Nonspecific skin changes were noted in 32 patients (4.26%).
Conclusions:
- Cutaneous manifestations are a notable feature in a subset of patients with internal malignancy.
- Herpes zoster was the most frequent nonspecific skin lesion observed.
- The study underscores the need for dermatological evaluation in the comprehensive care of cancer patients.
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