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Updated: May 20, 2026

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete

Published on: January 24, 2025

Syphilis d' emblee.

Sunil K Gupta¹, Aarti Bhattacharya, Rr Singh

¹Department of Skin, V.D. and Leprosy, HIMS, Barabanki, Uttar Pradesh, India. dr.sunil_30@yahoo.co.in

Indian Journal of Dermatology

|July 28, 2012

Summary

This case report highlights a rare presentation of syphilis, known as syphilis d'emblée, in a 28-year-old male. The patient developed a lip lesion and widespread rash following a blood transfusion, confirmed by diagnostic tests.

Area of Science:

Dermatology
Infectious Diseases
Venereology

Background:

Syphilis is a sexually transmitted infection caused by *Treponema pallidum*.
Syphilis d'emblée is a rare clinical presentation characterized by the simultaneous appearance of a primary chancre and secondary syphilitic lesions.
Delayed diagnosis of syphilis can lead to severe long-term complications.

Purpose of the Study:

To report a rare case of syphilis d'emblée.
To emphasize the importance of considering syphilis in patients with unusual dermatological presentations.
To highlight the diagnostic challenges and clinical significance of syphilis d'emblée.

Main Methods:

A case study of a 28-year-old male patient presenting with a lip lesion and generalized rash.

Keywords:

Blood transfusion VDRL syphilis d’ emblee

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Clinical examination and patient history, including a history of blood transfusion.

Histopathological examination of the lip lesion.

Serological tests: Venereal Disease Research Laboratory (VDRL) and TPHA (Treponema pallidum hemagglutination assay).

Main Results:

The patient presented with a single gray-white plaque on the lower lip and multiple papulosquamous lesions on the body.
Histopathology and reactive VDRL and TPHA tests confirmed the diagnosis of syphilis.
The clinical presentation was consistent with syphilis d'emblée.

Conclusions:

Syphilis d'emblée is a rare but important clinical entity that requires a high index of suspicion for diagnosis.
Dermatologists and infectious disease specialists should consider syphilis in the differential diagnosis of mucocutaneous lesions, especially in patients with risk factors.
Early diagnosis and treatment are crucial to prevent the progression and complications of syphilis.