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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

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Related Experiment Video

Updated: May 20, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Autoimmune cytopenias in common variable immunodeficiency.

Jenna C Podjasek1, Roshini S Abraham

  • 1Division of Allergic Diseases, Department of Medicine, Mayo Clinic , Rochester, MN, USA.

Frontiers in Immunology
|July 28, 2012
PubMed
Summary
This summary is machine-generated.

Common variable immunodeficiency (CVID) involves low antibody levels and frequent infections. Autoimmune complications, like cytopenias, occur in CVID patients due to immune dysregulation, particularly involving specific B cell subsets.

Keywords:
Evans syndromeautoimmune cytopeniasautoimmune hemolytic anemiaautoimmune lymphoproliferative syndromecommon variable immunodeficiency (CVID)immune thrombocytopenia

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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Related Experiment Videos

Last Updated: May 20, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Area of Science:

  • Immunology
  • Hematology

Background:

  • Common variable immunodeficiency (CVID) is a primary humoral immunodeficiency characterized by hypogammaglobulinemia and impaired antibody function.
  • While infections are common, autoimmune complications affect up to two-thirds of CVID patients.
  • Autoimmune cytopenias (thrombocytopenia, anemia, neutropenia) are the most frequent autoimmune manifestations in CVID.

Purpose of the Study:

  • To review current understanding of autoimmune hematological manifestations in CVID.
  • To explore recent concepts regarding immune dysregulation and B cell subsets in CVID-associated autoimmunity.
  • To highlight treatment strategies for autoimmune hematological issues in CVID.

Main Methods:

  • Literature review of CVID, autoimmune complications, and hematological manifestations.
  • Analysis of B cell subset alterations (e.g., CD21 low B cells) in CVID with autoimmunity.
  • Synthesis of current research on the link between immune dysregulation and autoimmune cytopenias in CVID.

Main Results:

  • Autoimmunity in CVID, though seemingly paradoxical, reflects underlying immune dysregulation.
  • Expansion of CD21 low B cells, enriched for autoreactive antibodies, is observed in CVID patients with autoimmune cytopenias.
  • Correlations exist between specific B cell subsets (memory B cells, plasmablasts) and the presence of autoimmunity in CVID.

Conclusions:

  • Autoimmune hematological manifestations are significant complications of CVID, linked to specific B cell abnormalities.
  • Understanding immune dysregulation and B cell subsets offers insights into CVID autoimmunity.
  • Further research and targeted treatments are needed for autoimmune hematological conditions in CVID patients.