Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Renewal of Intestinal Stem Cells

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

Development of the Lymphatic System

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...

Lymphoid Cells and Tissues

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

B Cell Activation and Differentiation

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Maternal and clinical predictors of congenital toxoplasmosis: A prospective cohort study in Brazil.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026

Same author

Nociceptive innervation limits tertiary lymphoid structures to promote lung cancer.

Cell·2026

Same author

Robust Functionalized Cotton Fabrics with Zr-Based Tetrahedral Cages for Degrading a Chemical Warfare Agent Simulant.

ACS applied materials & interfaces·2026

Same author

From Intravenous to Subcutaneous Infliximab: the Same but Different? Real-World Evidence from a Tertiary Center.

Acta gastroenterologica Latinoamericana·2025

Same author

Predictors of Willingness to Undergo Back Surgery: A Survey of Australian Privately Insured Adults with Chronic Back Pain Authors.

Australian health review : a publication of the Australian Hospital Association·2025

Same author

Neuroepithelial VIP-VIPR1 interactions differentially control enteric type 1 and type 2 immunity.

Nature immunology·2025

Search research articles

Related Experiment Video

Updated: May 20, 2026

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

Stroma cell priming in enteric lymphoid organ morphogenesis.

Manuela Ferreira¹, Rita G Domingues, Henrique Veiga-Fernandes

¹Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisboa, Portugal.

Frontiers in Immunology

|July 28, 2012

Summary

Understanding lymphoid organ development is key for immune surveillance. New research highlights mesenchymal and lymphoid tissue initiator cells in early secondary lymphoid organ (SLO) formation, offering fresh insights into immune system development.

Keywords:

LTin cells enteric lymphoid organ morphogenesis stroma cells

More Related Videos

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers

Published on: July 26, 2019

Isolation of Murine Lymph Node Stromal Cells

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

Related Experiment Videos

Last Updated: May 20, 2026

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers

Published on: July 26, 2019

Isolation of Murine Lymph Node Stromal Cells

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

Area of Science:

Immunology
Developmental Biology
Anatomy

Background:

Secondary lymphoid organs (SLOs) are crucial for immune surveillance and response.
SLO development primarily occurs in utero, with tertiary lymphoid structures forming later in life.
Lymphoid tissue inducer (LTi) cell recruitment and interaction with stroma cells are vital for SLO formation.

Purpose of the Study:

To explore the early phases of secondary lymphoid organ (SLO) development.
To investigate the roles of mesenchymal and lymphoid tissue initiator cells in lymphoid organogenesis.
To elucidate the poorly understood initial events priming stroma cells for LTi cell recruitment.

Main Methods:

Review of recent findings on lymphoid organogenesis.
Discussion of enteric lymphoid organs genesis.
Focus on emerging research in early lymphoid morphogenesis.

Main Results:

Recent discoveries emphasize the role of mesenchymal and lymphoid tissue initiator cells in early SLO development.
New perspectives are emerging on the initial cellular and molecular events driving lymphoid morphogenesis.
The precise mechanisms initiating stroma cell priming for LTi cell recruitment remain an active area of investigation.

Conclusions:

Early events involving mesenchymal and lymphoid tissue initiator cells are critical for SLO formation.
Further research into these early phases will enhance our understanding of lymphoid organ development.
This study provides a foundation for future investigations into the intricate process of lymphoid morphogenesis.