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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Related Experiment Video

Updated: May 20, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Immunoregulation of bone remodelling.

Ajai Singh1, Abbass A Mehdi, Rajeshwer N Srivastava

  • 1Department of Orthopaedics, Co Trauma Center I/C, C S M Medical University, Lucknow, India.

International Journal of Critical Illness and Injury Science
|July 28, 2012
PubMed
Summary
This summary is machine-generated.

Bone remodeling involves a balance between formation and resorption. This review explores how the immune system, particularly T cells, influences bone loss in diseases like osteoporosis and autoimmune conditions.

Keywords:
Bone remodelingimmunoregulationosteoblastsosteoclastsreceptor activator of nuclear factor kB ligand

More Related Videos

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

Related Experiment Videos

Last Updated: May 20, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

Area of Science:

  • Immunology
  • Orthopedics
  • Physiology

Background:

  • Bone remodeling is a continuous process crucial for skeletal strength, balancing bone formation and resorption.
  • The interplay between the skeletal and immune systems is increasingly recognized as vital for maintaining bone health.
  • Dysregulation in this interaction can lead to bone loss associated with inflammatory and autoimmune diseases.

Purpose of the Study:

  • To provide insight into the complex interactions between bone remodeling and the host immunological environment.
  • To summarize recent advancements in understanding the skeletal-immune system connection.
  • To explore the role of immune cells and molecules in bone metabolism.

Main Methods:

  • Literature review of current research on bone remodeling and immunology.
  • Analysis of molecular mechanisms linking immune responses to osteoclastogenesis.
  • Examination of shared pathways and molecules between skeletal and immune systems.

Main Results:

  • T cells directly and indirectly enhance receptor activator of nuclear factor kB ligand (RANKL) expression, promoting osteoclastogenesis.
  • Numerous cytokines, chemokines, transcription factors, and co-stimulatory molecules are shared between the skeletal and immune systems.
  • Ongoing research aims to elucidate the precise roles and regulatory mechanisms of these shared factors.

Conclusions:

  • Understanding the immune system's influence on bone remodeling is critical for managing bone loss.
  • This knowledge may lead to novel therapeutic strategies for osteoporosis and inflammatory/autoimmune diseases.
  • Further research into shared skeletal-immune pathways holds significant clinical potential.