[Diagnosis of cholestatic forms of viral hepatitis, its complications and outcomes]

Cholestatic virus hepatitis (CVH) patients were examined for blood levels of free oxyproline, cholesterol and triglycerides to evaluate connective tissue in walls of the ducts and adjacent area. Significantly elevated levels of free oxyproline, cholesterol and triglycerides occurred in CVH. A 3--5--fold increase in oxyproline and cholesterol was typical for protracted and chronic CVH evolving due to sclerosing cholangitis. The rise of triglycerides proved moderate. In initial and apparent biliary hepatic cirrhosis triglyceride levels stood within normal range while those of oxyproline and cholesterol were on the increase. The changes in the indices indicative of the inflammation, sclerosis or proliferation of the connective tissue in the biliary ducts walls may suggest CVH complications, prognosticate outcomes, facilitate differential diagnosis with other hepatic lesions.