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Related Concept Videos

Blank Solutions00:56

Blank Solutions

A blank solution is a solution that does not contain the analyte, or the substance of interest being tested or measured. It is typically prepared using the same reagents and procedure as the sample solution but without adding the analyte. The primary purpose of preparing a blank solution is to account for any background interference or contamination that may affect the accuracy and reliability of the analytical method.
In some experimental cases, the reagents, solvents, or lab equipment used in...
Sample Preparation for Analysis: Overview01:21

Sample Preparation for Analysis: Overview

Sample preparation is an essential step in the analytical process. It involves preparing a sample so that it can be analyzed accurately. The goal is to extract the analyte, the substance you want to measure, from the sample while removing any components that may interfere with the analysis. Sample preparation techniques vary depending on the physical state of the sample.
Bulk or large solid samples are typically reduced in size using grinding, crushing, or milling techniques to increase the...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Sample Handling01:02

Sample Handling

Transportation of samples from the collection point to the laboratory, as well as storage and preservation techniques, are crucial for maintaining sample integrity and ensuring accurate and reliable test results.
Samples should be transported carefully from collection points to the laboratory. They should be properly sealed and clearly labeled to prevent cross-contamination. To preserve the sample integrity, optimal temperature conditions during transport are essential. This could involve using...
High-Performance Liquid Chromatography: Introduction01:11

High-Performance Liquid Chromatography: Introduction

High-performance liquid chromatography(HPLC), formerly referred to as High-pressure liquid chromatography, is a powerful technique used to separate, identify, and quantify components in complex mixtures. The term "high pressure" refers to using high pressure to push the liquid mobile phase through the tightly packed columns.
In HPLC, two phases play a critical role in the separation process:

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Correction: Bukvić et al. Effects of High-Intensity Training on Complete Blood Count, Iron Metabolism, Lipid Profile, Liver, and Kidney Function Tests of Professional Water Polo Players. <i>Diagnostics</i> 2024, <i>14</i>, 2014.

Diagnostics (Basel, Switzerland)·2026
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Correction: Bukvić et al. The Association of Serum Calprotectin with Fitness Indicators and Biochemical Markers in High-Level Athletes: A Continuous Dynamic Monitoring During One Competitive Season. <i>Sports</i> 2023, <i>11</i>, 243.

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Verification of fCAL turbo Buhlmann reagent for determining serum calprotectin.

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Pentraxin 3 stability in serum and urine samples at -20 °C during a 4-week period.

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New insights in preanalytical quality.

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Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
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Preanalytical phase--a continuous challenge for laboratory professionals.

Ana-Maria Simundic, Giuseppe Lippi

    Biochemia Medica
    |July 31, 2012
    PubMed
    Summary

    The preanalytical phase of laboratory testing faces significant challenges due to non-standardized procedures and low guideline compliance, impacting patient safety. Harmonizing the management of unacceptable specimens is crucial for improving laboratory quality and establishing future evidence-based recommendations.

    Area of Science:

    • Clinical Laboratory Science
    • Medical Diagnostics

    Background:

    • The preanalytical phase is the most vulnerable stage in laboratory testing, presenting major challenges for laboratory professionals.

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  • Current preanalytical activities, specimen management, and reporting policies lack global standardization and harmonization.
  • Compliance with existing guidelines for blood sampling, transportation, and handling is notably low, particularly outside direct laboratory supervision.