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Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis

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Initial presenting features in gestational trophoblastic neoplasia: does a decade make a difference?

Stacey Killick¹, Jane Cook, Sarah Gillett

¹Sheffield Centre for Trophoblastic Disease, Weston Park Hospital, Sheffield, UK. skillick@hotmail.co.uk

The Journal of Reproductive Medicine

|July 31, 2012

Summary

Gestational trophoblastic neoplasia (GTN) diagnosis has improved, with earlier detection via ultrasound and fewer repeat procedures. Treatment trends show an increased chemotherapy use for GTN patients.

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In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells

In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells

Published on: March 16, 2017

Area of Science:

Gynecology
Oncology
Obstetrics

Background:

Gestational trophoblastic neoplasia (GTN) is a rare complication of pregnancy.
Early diagnosis and appropriate management are crucial for favorable outcomes.

Purpose of the Study:

To compare the initial clinical presentation and management of GTN patients between two distinct time periods (1996-1998 and 2006-2008).
To identify trends in diagnosis and treatment over time.

Main Methods:

Retrospective review of medical records for GTN patients (excluding PSTT) treated at Weston Park Hospital.
Analysis of clinical presentation features, diagnostic methods, and treatment interventions.
Comparison of data from 1996-1998 (n=79) and 2006-2008 (n=139).

Main Results:

Abnormal vaginal bleeding remains the most common presentation.
Proportion of abnormal ultrasound scans at diagnosis increased from 1% to 12%.
Mean gestational age at diagnosis decreased from 11.3 to 10.1 weeks.
Mean number of evacuations reduced, with a significant decrease in repeat evacuations.
Chemotherapy use for GTN increased from 4.2% to 6.7%.

Conclusions:

Advancements in ultrasound technology and expertise likely contribute to earlier GTD diagnosis.
A shift towards a higher threshold for repeat evacuations was observed.
Increased proportion of GTN patients received chemotherapy, indicating evolving treatment strategies.