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Updated: May 20, 2026
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
Effect of Renshen polysaccharides on oxidative injury in kidney IR rabbits
Zhangshun Liu1, Chao Li, Qin Zhang
1Department of Urology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China.
Abstract:
There is increasing evidence to suggest that reactive oxygen metabolites (ROMs) play a role in the pathogenesis of ischemia/reperfusion (I/R) injury in the kidney. This study was designed to determine the possible protective effect of Renshen polysaccharides (RSP) on renal ischemia/reperfusion (I/R) injury. Results showed that the polysaccharides of Renshen consisted mainly of glucose (29.21%), mannose (6.54%), rhamnose (4.34%), arabose (6.92%), galactose (18.41%). In addition, kidney lipid peroxidation level in IR rabbits were markedly increased, whereas antioxidant enzymes activities were significantly decreased. Renshen polysaccharides pre-treatment could decrease oxidative injury in kidney of IR rabbits.
