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Updated: Feb 15, 2026
08:03
Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model
Published on: July 12, 2018
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Third-generation cephalosporin-resistant Vibrio cholerae, India
Jharna Mandal1, Vilwanathan Sangeetha, Vithiya Ganesan
1Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Emerging Infectious Diseases
|July 31, 2012
Summary
A rare Vibrio cholerae strain resistant to third-generation cephalosporins was identified. This strain carried blaDHA-1 and blaNDM-1 genes, highlighting the need for antimicrobial resistance monitoring.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Vibrio cholerae is a significant human pathogen.
- Resistance to third-generation cephalosporins in V. cholerae is uncommon.
- Emergence of antimicrobial resistance poses a global health threat.
Purpose of the Study:
- To report the detection and characterization of a V. cholerae strain exhibiting unusual resistance patterns.
- To identify the genetic basis for the observed antimicrobial resistance.
Main Methods:
- Phenotypic testing including AmpC disk test, modified Hodge test, and EDTA disk synergy test.
- Genotypic analysis to detect specific resistance genes.
- Antimicrobial drug susceptibility profiling.
Main Results:
- The V. cholerae strain was negative for extended-spectrum β-lactamase (ESBL) production.
- The strain tested positive for AmpC, modified Hodge, and EDTA disk synergy tests.
- The blaDHA-1 and blaNDM-1 genes were identified in the V. cholerae strain.
Conclusions:
- The study identified a rare V. cholerae strain with resistance to third-generation cephalosporins.
- The presence of blaDHA-1 and blaNDM-1 genes contributes to the observed resistance.
- Continuous monitoring of V. cholerae antimicrobial susceptibility profiles is crucial.
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