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ALDH2 mediates 5-nitrofuran activity in multiple species

Linna Zhou1, Hironori Ishizaki, Michaela Spitzer

  • 1School of Chemistry and Biomedical Sciences Research Complex, University of St. Andrews and EaStCHEM, St. Andrews, Fife, Scotland KY16 9ST, UK.

Chemistry & Biology
|July 31, 2012
PubMed
Summary

This study identifies a conserved interaction between aldehyde dehydrogenase 2 (ALDH2) and 5-nitrofuran drugs across species. This discovery may help manage toxic side effects of these important antimicrobial prodrugs.

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