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Related Experiment Video

Updated: May 20, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Brain autoimmunity: the CD8 question(s).

Hartmut Wekerle¹, Gurumoorthy Krishnamoorthy

¹Max-Planck-Institute of Neurobiology, Am Klopferspitz 18, Martinsried, Germany. mcollins.immunology@verizon.net

|July 31, 2012

Summary

This summary is machine-generated.

The purging of central nervous system (CNS)-specific CD8(+) T cell repertoire requires direct contact with antigen-expressing oligodendrocytes. Inflammation can shift this balance, potentially leading to autoimmunity.

Area of Science:

Neuroimmunology
T cell immunology
Central nervous system autoimmunity

Background:

CD8(+) T cells play a critical role in adaptive immunity.

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