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Potential role of prokineticin 2 in experimental varicocele-induced rat testes
Li-Hui Tu1, Li-Li Yu, Cheng-Liang Xiong
1Institute of Family Planning Research, Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Objective:
To determine the possible role of prokineticin 2 in varicocele by inducing varicoceles in adult rats.
Methods:
Forty male Sprague-Dawley rats were used for sham operation (n = 10) and varicocele (n = 30) groups. Experimental varicocele was induced by partial ligation of the left renal vein in the varicocele, whereas the sham operation group only received a sham induction of varicocele. Left testes were harvested for real-time quantitative polymerase chair readtion analysis 2, 4, and 8 weeks after the induction of varicocele.
Results:
The expression of prokineticin 2 mRNA in 8-week varicocele-induced rats was significantly higher (P < .05) than that in the sham operation group.
Conclusion:
The present study suggests that prokineticin 2 expression is increased by varicocele induction and it may have a role in varicocele-induced infertility.
