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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Preventive Healthcare Services01:30

Preventive Healthcare Services

Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:

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Related Experiment Video

Updated: May 20, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

Cancer risk models and preselection for screening.

Inge Stegeman1, Patrick M Bossuyt

  • 1Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, Netherlands. i.stegeman@amc.nl

Cancer Epidemiology
|July 31, 2012
PubMed
Summary

Cancer risk models can improve cancer screening by identifying individuals at higher risk, potentially personalizing screening invitations beyond age. Further studies are needed to confirm their effectiveness and equity.

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An R-Based Landscape Validation of a Competing Risk Model
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An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Published on: September 27, 2024

An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

Area of Science:

  • Oncology
  • Preventive Medicine
  • Biostatistics

Background:

  • Current cancer screening programs (breast, cervical, colorectal) primarily use age-based criteria.
  • Age is a proxy for cancer risk, but individual risk varies due to other factors.
  • Excluding younger and older individuals from screening may miss treatable cancers.

Purpose of the Study:

  • To systematically review existing risk models for breast, cervical, and colorectal cancer screening.
  • To evaluate the development, validation, and impact analysis phases of these risk models.
  • To assess the potential of risk models to refine population-based screening strategies.

Main Methods:

  • Systematic literature review of cancer risk models for breast, cervical, and colorectal cancers.
  • Evaluation of models based on derivation, validation, and impact analysis stages.
  • Data collection and analysis conducted in August 2010.

Main Results:

  • Two colorectal, four breast, and three cervical cancer risk models were identified.
  • External validation was confirmed for one colorectal and four breast cancer models; none for cervical cancer models.
  • No studies evaluated the impact of these risk models on the effectiveness of population screening.

Conclusions:

  • Risk models for pre-selecting individuals for cancer screening have been developed.
  • These models hold potential for improving screening selection, aiding personal decisions, and reducing adverse effects.
  • Further research is required to validate these hypotheses and address practicalities, equity, and reliability.