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Published on: October 31, 2012
Serum levels of interleukin-9 during acute rejection in liver transplantation
E Fábrega1, M López-Hoyos, D San Segundo
1Gastroenterology and Hepatology Unit, Faculty of Medicine, University Hospital Marqués de Valdecilla, Santander, Spain. digfge@humv.es
Introduction:
Interleukin-9 (IL-9) has been cast as a player in autoimmunity, but its role in liver transplantation remains to be clarified. The aim of our study was to investigate the time course of IL-9 serum levels during hepatic allograft rejection.
Methods:
IL-9 serum levels were determined in 34 healthy subjects and 50 hepatic transplant recipients. The patients were divided into two groups: group I was composed of 15 patients with acute rejection episodes, and group II, 35 patients free of this problem. Samples were collected on days 1 and 7 after liver transplantation and on the day of liver biopsy.
Results:
The concentrations of IL-9 were similar in the rejection and nonrejection groups over the entire postoperative period. The whole transplant group, including those with stable graft function, showed higher IL-9 serum levels than the controls at all times after liver transplantation.
Conclusions:
These preliminary results suggest a lack of participation of IL-9 in human liver allograft rejection.
