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Donor complications among 500 living donor liver transplantations at a single center

D Ozgor1, A Dirican, M Ates

  • 1Department of Surgery and Liver Transplantation Unit, Inonu University, Malatya, Turkey.

Transplantation Proceedings
|July 31, 2012
PubMed

Insights

Living donor liver transplantation (LDLT) involves donor hepatectomy with an 18.6% complication rate, but no donor mortality was observed. Biliary issues were most common, with most complications being minor.

Area of Science:

  • Hepatobiliary Surgery
  • Transplant Surgery
  • Surgical Outcomes Research

Background:

  • Increasing demand for liver transplantation necessitates living donor liver transplantation (LDLT).
  • Donor safety is paramount in LDLT procedures.
  • The Clavien classification system is utilized to standardize complication grading.

Purpose of the Study:

  • To retrospectively analyze the incidence and severity of complications in living liver donors.
  • To evaluate donor safety outcomes following hepatectomy for LDLT.

Main Methods:

  • Retrospective analysis of 500 consecutive living donors undergoing hepatectomy for LDLT.
  • Application of the Clavien classification system to grade all reported complications.
  • Follow-up of donors for a mean of 30 months post-surgery.

Main Results:

  • 18.6% of donors (93/500) experienced 149 complications; no donor mortality occurred.
  • The majority of complications were minor (Grade I/II), while major complications (Grade III/IV) occurred in 42.1% of complicated cases.
  • Biliary complications were the most frequent, occurring in 7.7% of donors.

Conclusions:

  • Living liver donation is associated with a manageable range of complications.
  • The Clavien classification effectively grades the severity of donor complications in LDLT.
  • LDLT donor hepatectomy demonstrates a favorable safety profile with no reported mortality.
Abstract

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