Related Experiment Video
Updated: May 20, 2026
10:11
Using Quantitative Real-time PCR to Determine Donor Cell Engraftment in a Competitive Murine Bone Marrow Transplantation Model
Published on: March 7, 2013
Donors with malignancies-risk or chance?
1Department of Urology, Heinrich Heine University Hospital Duesseldorf, Germany. markus.giessing@med.uni-duesseldorf.de
Transplantation Proceedings
|July 31, 2012
Summary
Transplant physicians are exploring using kidneys from donors with cancer to address organ shortages. Evidence supports accepting these kidneys, with decisions based on tumor type and recipient factors.
Area of Science:
- Nephrology
- Transplantation Surgery
- Oncology
Background:
- Significant disparity exists between donor kidney supply and recipient demand in renal transplantation.
- This shortage necessitates exploring alternative donor sources, including those with a history of malignancy.
- Kidneys from donors with renal or ureteral tumors are increasingly considered for transplantation.
Purpose of the Study:
- To review current evidence and strategies for utilizing kidneys from donors with malignant tumors.
- To outline decision-making criteria for accepting such organs for renal transplantation.
- To discuss donor tumor characteristics and recipient factors influencing transplantation outcomes.
Main Methods:
- Systematic literature review using Medline and PubMed databases.
- Analysis of studies evaluating the safety and efficacy of transplanting kidneys from donors with malignancy.
- Synthesis of guidelines and expert opinions on donor selection and management.
Main Results:
- Growing evidence supports the viability of using kidneys from donors with renal or ureteral malignancies.
- Successful transplantation outcomes are achievable when specific donor and recipient criteria are met.
- Careful donor tumor assessment and recipient evaluation are crucial for minimizing risks.
Conclusions:
- Accepting kidneys from donors with malignancy is a viable strategy to increase organ availability.
- Transplantation decisions require a multidisciplinary approach, considering tumor biology, surgical factors, and recipient status.
- Further research is warranted to optimize protocols for using these organs and improve long-term graft survival.
Related Concept Videos
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
01:24Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
02:59Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...