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Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

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Related Experiment Video

Updated: May 20, 2026

Characterizing Modulators of Protease-Activated Receptors with a Calcium Mobilization Assay Using a Plate Reader
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Endothelin XII.

Matthias Barton, Masashi Yanagisawa, Paul M Vanhoutte

    Life Sciences
    |July 31, 2012
    PubMed
    Summary
    This summary is machine-generated.

    Research into endothelin, a potent vasoconstrictor, began 25 years ago. Endothelin receptor antagonism is now a key treatment for pulmonary arterial hypertension.

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    Area of Science:

    • Cardiovascular Research
    • Molecular Biology
    • Pharmacology

    Background:

    • The discovery of endothelin in 1988 marked a significant advancement in understanding endothelium-dependent vasoconstriction.
    • This discovery initiated a new research field, leading to the establishment of International Conferences on Endothelin.
    • The Twelfth International Conference on Endothelin convened in Cambridge, UK, in September 2011, showcasing original research.

    Discussion:

    • Endothelin receptor antagonism has been a validated therapeutic strategy for over a decade.
    • This treatment is orally active and specifically targets patients with pulmonary arterial hypertension.
    • The extensive body of research, with over 25,000 papers published, underscores the impact of endothelin studies.

    Key Insights:

    • The identification of the endothelin gene and peptide sequence was a landmark event in cardiovascular science.
    • Endothelin's role in vasoconstriction has been extensively investigated since its discovery.
    • The development of endothelin receptor antagonists represents a major therapeutic breakthrough.

    Outlook:

    • Continued research into endothelin pathways may reveal further therapeutic targets.
    • The International Conferences on Endothelin serve as a crucial platform for disseminating cutting-edge research.
    • Future studies will likely build upon the established foundation of endothelin's role in cardiovascular health and disease.