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Updated: May 20, 2026

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
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Published on: March 20, 2021

Thrombotic risk in patients undergoing peripheral stem cell apheresis and low-molecular weight heparin prophylaxis

Patrizia Politi1, Suzy M T Durazzi, Francesco Picardi

  • 1Transfusion Medicine Service, Azienda Ospedaliera Marche Nord, San Salvatore Hospital, Pesaro, Italy. p.politi@ospedalesansalvatore.it

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|July 31, 2012
PubMed

Patients undergoing peripheral blood stem cell (PBSC) collection for autologous transplantation may have a greater incidence of thrombosis due to a number of risk factors (RFs). These factors may be related to the patient himself (history of thromboembolism, tumour type and stage, treatment), to the procedure and/or to the mobilizing agents used. In our study of 97 patients, 32 were considered high risk (HR) patients and were therefore treated with a low prophylactic dose of enoxaparin the evening before stem cell apheresis. Neither thrombotic nor hemorrhagic complications were observed, even though pre-apheresis platelet levels were below 50×10(9)l(-1) in 19 procedures.

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