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Updated: May 20, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
Published on: May 15, 2019
Sepantronium bromide (YM155) induces disruption of the ILF3/p54(nrb) complex, which is required for survivin
Tomohiro Yamauchi1, Naoto Nakamura, Masashi Hiramoto
1Drug Discovery Research, Astellas Pharma, Inc., Tsukuba-shi, Ibaraki, Japan. tomohiro.yamauchi@astellas.com
Abstract:
YM155, a small-molecule survivin suppressant, specifically binds to the transcription factor ILF3, which regulates the expression of survivin[1]. In this experiment we have demonstrated that p54(nrb) binds to the survivin promoter and regulates survivin expression. p54(nrb) forms a complex with ILF3, which directly binds to YM155. YM155 induces disruption of the ILF3/p54(nrb) complex, which results in a different subcellular localization between ILF3 and p54(nrb). Thus, identification of molecular targets of YM155 in suppression of the survivin pathway, might lead to development of its use as a novel potential target in cancers.
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