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Real-Time Quantification of Reactive Oxygen Species in Neutrophils Infected with Meningitic Escherichia Coli
Published on: April 20, 2021
Eosinophilic meningitis secondary to intravenous vancomycin
Ruchika Kazi1, Haseeb A Kazi, Cara Ruggeri
1Department of Internal Medicine, St. Luke's University Hospital, Bethlehem, PA, USA. kazir@slhn.org
Journal of Pharmacy Practice
|July 31, 2012
Summary
Eosinophilic meningitis, often caused by parasites, can also arise from medications. This report details the first case of eosinophilic meningitis linked to systemic vancomycin treatment in a 32-year-old male.
Area of Science:
- Neurology
- Infectious Diseases
- Pharmacology
Background:
- Eosinophilic meningitis presents with diverse causes, including parasitic infections and noninfectious agents like medications.
- Identifying the specific etiology is crucial for appropriate patient management and treatment strategies.
Observation:
- A 32-year-old male developed symptoms consistent with eosinophilic meningitis.
- The patient was undergoing treatment with intravenous vancomycin for an unspecified condition.
Findings:
- Cerebrospinal fluid analysis revealed eosinophilic pleocytosis, indicative of eosinophilic meningitis.
- No infectious or other identifiable noninfectious causes were found, apart from vancomycin exposure.
- This case marks the first documented instance of eosinophilic meningitis associated with systemic vancomycin administration.
Implications:
- Vancomycin should be considered a potential cause of drug-induced eosinophilic meningitis.
- Further investigation into the mechanisms of vancomycin-induced neurotoxicity is warranted.
- Clinicians should maintain a high index of suspicion for medication-related causes in eosinophilic meningitis cases.
Keywords:
infectious disease
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