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Related Concept Videos

What is Homeostasis?01:16

What is Homeostasis?

Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F). Physiological...
Homeostatic Imbalance01:10

Homeostatic Imbalance

Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
However, sometimes these feedback loops fail,...
Positive and Negative Feedback Loops01:18

Positive and Negative Feedback Loops

Animal organs and organ systems constantly adjust to internal and external changes through a process called homeostasis ("steady state"). Examples of these changes include regulation of the level of glucose or calcium in the blood or internal responses to external temperatures. Homeostasis requires  maintaining an internal dynamic equilibrium:
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Transduction01:16

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...
Osmoregulation in Insects01:47

Osmoregulation in Insects

Malpighian tubules are specialized structures found in the digestive systems of many arthropods, including most insects, that handle excretion and osmoregulation. The tubules are typically arranged in pairs and have a convoluted structure that increases their surface area.

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Updated: May 20, 2026

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

ROS homeostasis during development: an evolutionary conserved strategy.

Jos H M Schippers1, Hung M Nguyen, Dandan Lu

  • 1Department of Molecular Biology, Institute of Biochemistry and Biology, University of Potsdam, Potsdam-Golm, Germany. schippers@mpimp-golm.mpg.de

Cellular and Molecular Life Sciences : CMLS
|July 31, 2012
PubMed
Summary
This summary is machine-generated.

Reactive oxygen species (ROS) regulate cell growth and development across life forms. This review explores how cells sense and utilize ROS, revealing their ancient role as universal developmental regulators.

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Last Updated: May 20, 2026

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Area of Science:

  • Developmental Biology
  • Cellular Biology
  • Evolutionary Biology

Background:

  • Cellular proliferation and differentiation are fundamental to multicellular development.
  • Reactive oxygen species (ROS) play critical roles in regulating these processes.
  • ROS's influence on cell fate is conserved across diverse life forms, from prokaryotes to eukaryotes.

Purpose of the Study:

  • To review the distinct roles of various ROS in plant development, specifically in Arabidopsis roots.
  • To discuss the evolutionary perspective of ROS perception and cellular function.
  • To highlight the common evolutionary origins of ROS sensing mechanisms and their role in development.

Main Methods:

  • Literature review of recent studies on ROS and cellular development.
  • Analysis of transcriptional regulation in response to ROS.
  • Comparative evolutionary analysis of redox-sensing mechanisms.

Main Results:

  • Distinct ROS types differentially regulate proliferation and differentiation.
  • ROS modulation is controlled transcriptionally.
  • ROS signaling and sensing mechanisms show evolutionary conservation.

Conclusions:

  • ROS are ancient, universal regulators of development.
  • Organisms utilize conserved strategies for sensing and responding to ROS.
  • Understanding ROS pathways offers insights into fundamental developmental processes.