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Salivary Glands and Saliva

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Related Experiment Video

Updated: May 20, 2026

Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics

Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics

Published on: May 17, 2019

Salivary gland carcinomas.

Tobias Ettl¹, Stephan Schwarz-Furlan, Martin Gosau

¹Department of Oral and Maxillofacial Surgery, Regensburg University, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany. tobias.ettl@ukr.de

Oral and Maxillofacial Surgery

|July 31, 2012

Summary

Salivary gland carcinomas are rare, complex tumors. Advances in understanding their genetics and improved diagnostic imaging aid treatment, though systemic therapies for advanced stages remain challenging.

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Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers

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Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction

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Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers

Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers

Published on: July 15, 2019

Area of Science:

Oncology
Pathology
Surgical Oncology

Background:

Salivary gland carcinomas are rare, morphologically diverse tumors.
These neoplasms necessitate specialized surgical and adjuvant therapeutic strategies.

Purpose of the Study:

To review current knowledge on salivary gland carcinomas.
To highlight recent advancements in diagnosis, classification, and treatment.

Main Methods:

Systematic electronic search of PubMed for relevant studies.
Review of literature focusing on innovative and significant findings.

Main Results:

Genetic insights (aberrations, RTKs, tumor suppressors, methylation) advance etiological understanding.
New histological subtypes and a grading system are recognized; advanced imaging (DW-MRI, PET/CT) improves diagnosis.
Conservative parotid surgery with nerve monitoring is standard; neck dissection is crucial for high-grade lesions. Adjuvant (chemo)radiotherapy improves local control but not necessarily survival.

Conclusions:

Salivary gland carcinomas present a heterogeneous group of tumors.
Despite progress, these challenging tumors require multidisciplinary expertise for optimal management.