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Updated: May 20, 2026
03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophilic gastrointestinal diseases--clinically diverse and histopathologically confounding
Seema Aceves1, Ikuo Hirano, Glenn T Furuta
1Division of Allergy, Immunology, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Seminars in Immunopathology
|July 31, 2012
Summary
Eosinophilic gastrointestinal diseases (EGIDs) involve eosinophilic inflammation in the GI tract. Eosinophilic esophagitis (EoE) is the most common form, treated with diet and corticosteroids.
Area of Science:
- Gastroenterology
- Immunology
- Pathology
Background:
- Eosinophilic gastrointestinal diseases (EGIDs) are chronic conditions.
- Symptoms arise from eosinophilic inflammation in the GI tract.
- Other causes of eosinophilia must be excluded for diagnosis.
Purpose of the Study:
- To summarize the characteristics of EGIDs.
- To highlight eosinophilic esophagitis (EoE) as a common EGID.
- To describe diagnostic features and treatments.
Main Methods:
- Review of existing literature on EGIDs.
- Description of histological findings in EoE.
- Summary of current treatment modalities.
Main Results:
- EGIDs are defined by eosinophilic inflammation in the GI tract.
- Eosinophilic esophagitis (EoE) is the most prevalent EGID globally.
- Histology shows dense eosinophilia, degranulation, microabscesses, basal zone hyperplasia, and rete peg elongation.
Conclusions:
- Diagnosis of EGIDs requires excluding other causes of eosinophilia.
- Eosinophilic esophagitis (EoE) is a significant antigen-driven disease.
- Dietary exclusions and topical corticosteroids are primary treatments for EoE.
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