Related Experiment Video
Updated: May 20, 2026

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
Published on: March 24, 2019
In silico study of Alzheimer's disease in relation to FYN gene
1Bioinformatics Division, School of Biosciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India. aanand@vit.ac.in
Abstract:
To understand the role of FYN (Fibroblast Yes related novel) gene products in relation to neurodegeneration and Alzheimer's disease we have analyzed the SNPs (single nucleotide polymorphism) associated with this gene. This can help us to understand the genetic variations that can alter the function of the gene products. A total of 3463 SNPs are investigated for FYN. To determine whether a non-synonymous SNP (nsSNP) in this gene affects its protein product, we used certain computational tools which predicted two nsSNPs (rs1801109, rs1801121) to have significant damaging effects. The amino acid change for rs1801109 is from alanine to aspartate, i.e. from a neutral, non-polar amino acid to a polar, acidic amino acid (electrically charged) and for rs1801121 it is from isoleucine to phenylalanine, i.e. from an aliphatic, hydrophobic molecule to an aromatic, highly hydrophobic residue. Hence, due to the complete change in charges and side chains of the amino acid residues brought about by these nsSNPs, respectively, might affect the structure and function of the protein. The results presented from this in silico study will open up new prospect for genetic analysis of FYN gene and their correlation with clinical data will be very useful in understanding the genetics of Alzheimer's disease.
More Related Videos
11:57Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase
Published on: June 24, 2025
10:03Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons
Published on: August 16, 2020
Related Concept Videos
Alzheimer Disease ll: Pathophysiology
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease l: Introduction