Related Experiment Video

Updated: May 20, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Lipid profiles and outcome in patients treated by intravenous thrombolysis for cerebral ischemia

Katiuscia Nardi1, Stefan Engelter, Daniel Strbian

  • 1Stroke Unit and Department of Neurology, University Hospital of Lille, Lille, France.

Neurology
|July 31, 2012
PubMed

Insights

Lower high-density lipoprotein cholesterol (HDL-C) and triglyceride levels are linked to worse outcomes in ischemic stroke patients receiving IV thrombolysis. These lipid levels may offer protective benefits post-stroke.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Lipid profiles, including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides, play a role in cardiovascular health.
  • The impact of specific lipid parameters on outcomes following acute ischemic stroke treated with intravenous thrombolysis requires further elucidation.

Purpose of the Study:

  • To investigate the association between lipid concentrations (LDL-C, HDL-C, triglycerides) and patient outcomes after ischemic stroke treated with IV thrombolysis.
  • To determine if low HDL-C or triglyceride levels, rather than LDL-C, are associated with poorer outcomes.

Main Methods:

  • An observational, multicenter, post hoc analysis was conducted using prospectively collected data from stroke thrombolysis registries.
  • Two statistical models were employed to address collinearity between total cholesterol (TC) and LDL-C, one using TC and the other using LDL-C.

Main Results:

  • Lower serum HDL-C and triglyceride levels were independently associated with increased 3-month mortality in ischemic stroke patients.
  • Higher HDL-C levels were associated with an excellent outcome (modified Rankin Scale score 0-1).
  • Lipid concentrations were not independently associated with symptomatic intracranial hemorrhage (ICH).

Conclusions:

  • Reduced HDL-C and triglyceride levels are independently linked to higher mortality rates following acute ischemic stroke.
  • These findings suggest a potential protective role for HDL-C and triglycerides in the acute phase of ischemic stroke.
  • The observed associations may be influenced by baseline comorbidities, nutritional status, or a direct physiological effect of these lipids.
Abstract

More Related Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...