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Pulmonary hypertension in an infant treated with ibuprofen

Arvind Sehgal1, Prasanna S N Kumarshingri

  • 1Monash Newborn, Monash Children's, Monash University, Melbourne, Australia. sehgalarvind@yahoo.ca

Indian Journal of Pediatrics
|July 31, 2012
PubMed

Insights

Ibuprofen is common for treating patent ductus arteriosus in preterm infants. However, rare cases show severe hypoxemia and pulmonary hypertension, possibly due to dosage or composition.

Area of Science:

  • Neonatalogy
  • Pharmacology
  • Pediatric Cardiology

Background:

  • Symptomatic patent ductus arteriosus (PDA) is prevalent in preterm infants.
  • Ibuprofen is a standard medical treatment for PDA closure.
  • Its efficacy is comparable to indomethacin.

Observation:

  • Few case reports document severe hypoxemia and pulmonary hypertension post-prophylactic ibuprofen.
  • These adverse events appear rare but serious.

Findings:

  • Cumulative dose effects of ibuprofen may be a contributing factor.
  • The chemical composition of ibuprofen could influence its safety profile.
  • Potential mechanisms for these complications in preterm infants are explored.

Implications:

  • Careful consideration of ibuprofen dosage and formulation is crucial for preterm infants.
  • Further research into the mechanisms underlying these rare adverse events is warranted.
  • This highlights the need for vigilant monitoring during PDA treatment.

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