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Related Experiment Video

Updated: May 20, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

Aging in the glomerulus.

Jocelyn E Wiggins¹

¹University of Michigan Health System, Division of Geriatrics, Department of Internal Medicine, 1560 MSRBII, Box 5676, Ann Arbor, MI 48109-5676, USA. wiggi@umich.edu

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

|July 31, 2012

Summary

This summary is machine-generated.

Kidney function naturally declines with age, often due to glomerulosclerosis. This review examines age-related glomerular changes, the impact of calorie restriction, and the role of podocytes and NFkB in aging kidneys.

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Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

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Assessment of Kidney Function in Mouse Models of Glomerular Disease

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Area of Science:

Nephrology
Gerontology
Cell Biology

Background:

Kidney function commonly declines with aging.
Age-associated glomerulosclerosis contributes significantly to this decline.
End-stage renal disease in older adults poses substantial patient and societal burdens.

Purpose of the Study:

To review age-related structural and functional changes in the glomerulus.
To discuss the role of calorie restriction in mitigating age-related kidney pathology.
To explore the significance of podocytes, NFkB signaling, and aging pathways in kidney function decline.

Main Methods:

Review of established literature on aging glomeruli.
Analysis of animal models and human biopsy data concerning podocyte function.
Examination of recent findings on gene expression, including nuclear factor kappa beta (NFkB) pathways.

Main Results:

Age-related changes in glomerular structure and function are well-documented.
Calorie restriction shows potential in modifying age-related kidney pathology.
Podocyte integrity and NFkB signaling are implicated in the aging kidney process.

Conclusions:

Understanding age-associated glomerular changes is crucial for managing kidney health in older populations.
Podocyte biology and specific gene expression pathways, like NFkB, are key areas for further research.
The relationship between aging pathways and kidney function decline warrants continued investigation for both normal and pathological aging.