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Updated: May 20, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

Aromatase in colon carcinoma.

Ryuichiro Sato¹, Takashi Suzuki, Yu Katayose

¹Department of Surgery, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

Anticancer Research

|July 31, 2012

Summary

Colon carcinoma exhibits elevated aromatase, an estrogen-producing enzyme. This suggests local estrogen synthesis within tumor tissues, potentially impacting estrogen-responsive malignancies.

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Area of Science:

Biochemistry
Oncology
Molecular Biology

Background:

Aromatase is a key enzyme in estrogen production, a target for estrogen receptor-positive breast cancer.
Human colon carcinoma is increasingly recognized as potentially estrogen-responsive.
The expression and role of aromatase in colon carcinoma remain largely uncharacterized.

Purpose of the Study:

To investigate the expression and localization of aromatase in human colon carcinoma.
To determine the correlation between aromatase expression and intratumoral estrogen concentrations.
To explore the relationship between aromatase expression and clinicopathological features of colon carcinoma.

Main Methods:

Immunohistochemistry was employed to detect aromatase protein expression in colon carcinoma tissues.

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Published on: September 11, 2012

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Last Updated: May 20, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)

Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)

Published on: September 11, 2012

Real-time polymerase chain reaction (PCR) was utilized to quantify aromatase mRNA levels.

Intratumoral estrogen concentrations, including estradiol, were measured.

Main Results:

Aromatase mRNA levels were significantly higher in colon carcinoma compared to non-neoplastic mucosa.
Aromatase immunoreactivity was observed in 65% of colon carcinoma cases, localized in the cytoplasm of carcinoma cells.
Aromatase expression showed a positive association with intratumoral estrogen levels, particularly estradiol in men.
Aromatase immunoreactivity correlated positively with tubular differentiation and inversely with Ki-67 labeling index.

Conclusions:

Colon carcinoma expresses functional aromatase, leading to local estrogen synthesis within tumor tissues.
These findings highlight the potential role of estrogen in colon carcinoma development and progression.
Further research into estrogen's actions in colon carcinoma is warranted, potentially informing therapeutic strategies.