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Updated: May 20, 2026
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Biochemical failure after carbon ion radiotherapy for prostate cancer
Jun Shimazaki1, Hiroshi Tsuji, Hitoshi Ishikawa
1Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan. shimajun@opal.famille.ne.jp
Background/Aim:
Biochemical failure after radiotherapy for prostate cancer occurs infrequently, but some cases progress to a poor outcome. The aim of this study was to examine prognosis after biochemical failure.
Patients And Methods:
A total of 728 patients were treated with carbon ion radiotherapy, and biochemical failure occurred in 90 (12.4%). Their outcomes were examined according to risk factors, histological findings, and androgen deprivation therapy (ADT).
Results:
Biochemical failure rates were 12%, 6%, and 15% in low-, intermediate- and high-risk patients. Most patients responded favorably to salvage therapy. Some high-risk patients (25%) progressed to poor outcome; half experienced failure after ADT, while the rest during ADT, indicating that ADT had a slight influence. Patients who died from their disease had approximately two years of biochemical failure-free time and three years of survival after failure. Their tumor showed the presence and the increased proportion of histologically high-grade growth patterns.
Conclusion:
Histological growth patterns and short biochemical failure-free time are prognostic factors for poor outcome regardless of ADT.
