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Split-Course Radiotherapy in Stage IV Head & Neck Cancer
B M Biswal1, N Ruzman, N M Ahmad
1Department of Nuclear Medicine, Radiotherapy & Oncology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
The Malaysian Journal of Medical Sciences : MJMS
|July 31, 2012
Summary
Split-course radiotherapy effectively identifies stage IV head and neck cancer patients suitable for curative treatment. This hypofractionated approach helps distinguish responders for further radical radiotherapy, improving outcomes.
Area of Science:
- Oncology
- Radiation Oncology
Background:
- Short-course hypo-fractionated radiotherapy is standard for palliative stage IV head and neck cancers.
- Many patients require further radiotherapy for curative intent, but identifying suitable candidates is challenging.
Purpose of the Study:
- To evaluate the conversion rate from palliative to curative intent using a split-course radiotherapy technique.
- To assess the efficacy of a hypofractionated split-course radiotherapy in stage IV head and neck cancers.
Main Methods:
- A prospective study involving 26 patients with stage IV head and neck cancers treated with 30 Gy in 10 fractions over 2 weeks.
- Tumor response assessed during and after radiotherapy; patients with complete or good partial response proceeded to further radical radiotherapy (30 Gy in 15 fractions).
Main Results:
- Complete response in 54% of patients, partial response in 23%, and no response in 23%.
- 61% of patients were suitable for radical radiotherapy after the initial course.
- 65% experienced improved well-being and quality of life; 1-year actuarial survival was 76%.
Conclusions:
- Split-course radiotherapy is a valuable technique for stage IV head and neck cancers.
- It effectively identifies patients who can benefit from curative-intent radiotherapy, distinguishing them from those who cannot.
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