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Related Concept Videos

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Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
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Related Experiment Video

Updated: May 20, 2026

Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens
09:19

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Pulmonary metastasis from pseudomyxoma peritonei.

Toshiyuki Kitai1

  • 1Department of Surgery, Kishiwada City Hospital, 1001 Gakuhara-cho, Kishiwada, Osaka 5968501, Japan.

Gastroenterology Research and Practice
|July 31, 2012
PubMed
Summary

Pseudomyxoma peritonei (PMP) is a rare condition characterized by mucinous ascites. Pulmonary metastasis from PMP, though rare, can be managed with surgical resection, offering long-term survival in some patients.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Gastroenterology

Background:

  • Pseudomyxoma peritonei (PMP) is a rare condition involving mucinous ascites due to mucin-producing tumors.
  • PMP's unique disseminating yet non-metastasizing behavior makes it a focus for surgical oncologists.
  • Lung is the most common site for extra-abdominal metastasis in PMP.

Purpose of the Study:

  • To review clinical findings and treatment outcomes of PMP with pulmonary metastasis.
  • To analyze the efficacy of surgical resection for pulmonary lesions in PMP patients.

Main Methods:

  • Review of eleven cases of pulmonary metastasis from PMP (10 literature, 1 case experience).
  • Analysis of clinical features, histological types, and treatment modalities.
  • Evaluation of outcomes following surgical resection of pulmonary lesions.

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Main Results:

  • Clinical features of PMP with pulmonary metastasis were similar to those without.
  • Low-grade mucinous neoplasm was the predominant histological type.
  • Seven patients underwent resection of pulmonary lesions; five achieved a disease-free state post-operatively.
  • Two cases showed rapid progression after resection, suggesting potential biological changes.

Conclusions:

  • Pulmonary metastasis from PMP is rare but manageable with surgical intervention.
  • Aggressive locoregional therapy, including cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, is crucial for PMP.
  • Surgical resection of pulmonary lesions can lead to long-term survival and cure in select PMP patients.
  • Further research is needed to understand biological changes post-surgery.