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Updated: May 20, 2026

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient
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Senescence Marker Protein 30: Functional and Structural Insights to its Unknown Physiological Function.

Stephanie H Scott1, Brian J Bahnson

  • 1Department of Chemistry & Biochemistry, University of Delaware, Newark, DE 19716, USA.

Biomolecular Concepts
|July 31, 2012
PubMed
Summary

Senescence marker protein 30 (SMP30) is a conserved protein vital for calcium homeostasis and vitamin C synthesis. This review explores its structure, enzymatic functions, and roles in diseases like osteoporosis and cancer.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Physiology

Background:

  • Senescence marker protein 30 (SMP30) is a multifunctional protein conserved across vertebrates.
  • It plays roles in cellular calcium homeostasis and ascorbate biosynthesis in non-primate mammals.
  • SMP30 exhibits enzymatic activities including aldonolactone and organophosphate hydrolysis.

Purpose of the Study:

  • To review recent advances in understanding the molecular structure, enzymatic activity, and physiological functions of SMP30.
  • To highlight the connection between SMP30's structure and its multifaceted roles.
  • To discuss SMP30's involvement in various physiological conditions.

Main Methods:

  • Literature review of recent studies on SMP30.
  • Analysis of X-ray crystallography data revealing SMP30's β-propeller structure.

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Published on: May 18, 2017

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Last Updated: May 20, 2026

Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient
08:06

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Published on: September 3, 2014

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
09:29

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Published on: May 18, 2017

  • Examination of reported enzymatic activities and protective effects.

    • Main Results:

    • SMP30 shares structural similarity with paraoxonase 1, indicating conserved functional domains.
    • Protective effects against apoptosis and oxidative stress have been documented.
    • SMP30 is implicated in conditions such as osteoporosis, liver fibrosis, diabetes, and cancer.

    Conclusions:

    • SMP30 is a highly conserved protein with significant physiological importance across mammals.
    • Understanding its structure-function relationship is crucial for elucidating its role in health and disease.
    • Further research into SMP30 could offer insights into therapeutic strategies for related conditions.