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Published on: May 10, 2017
Cutaneous T-cell lymphoma in asians
Min Soo Jang1, Dong Young Kang, Jong Bin Park
1Department of Dermatology, Kosin University College of Medicine, 34 Amnam-Dong, Seo-gu, Busan 602-702, Republic of Korea.
ISRN Dermatology
|July 31, 2012
Summary
Cutaneous T-cell lymphomas (CTCL) present differently in Asians, with higher rates of specific subtypes and unique lesion variations compared to Western populations. Geographic factors, including genetics and environment, influence these diverse clinicopathologic features.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Cutaneous T-cell lymphoma (CTCL) is a diverse group of skin-homing T-cell neoplasms.
- CTCL exhibits significant variation in clinical presentation, histology, immunophenotype, and prognosis.
Purpose of the Study:
- To examine the clinical-epidemiologic and histopathological features of CTCL specifically in Asian populations.
- To compare the prevalence of CTCL subtypes and lesion variants in Asia versus Western countries.
Main Methods:
- Review of clinical and histopathological data on CTCL cases in Asian individuals.
- Comparative analysis of CTCL epidemiology and characteristics between Asian and Western cohorts.
Main Results:
- Asia shows higher incidence rates for extranodal NK/T-cell lymphoma, hydroa vacciniforme-like lymphoma, subcutaneous panniculitis T-cell lymphoma, and adult T-cell leukemia/lymphoma.
- Conversely, cutaneous B-cell lymphomas are less common in Asia.
- Hypopigmented, pityriasis lichenoides-like, and ichthyosiform lesions of mycosis fungoides are more prevalent in Asian patients.
- Adult T-cell leukemia/lymphoma is endemic in specific regions of Japan.
Conclusions:
- Clinicopathologic characteristics of CTCL are geographically variable.
- Genetic and environmental factors are likely contributors to the observed geographic disparities in CTCL presentation and prevalence.
