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MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Related Experiment Video

Updated: May 20, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

Recent advances in miRNA-based diagnostic applications.

Lorenzo F Sempere¹

¹Department of Medicine, Geisel School of Medicine at Dartmouth, 1 Medical Center Drive, Lebanon, NH 03756, USA. lorenzo.f.sempere@dartmouth.edu

Expert Review of Molecular Diagnostics

|August 1, 2012

Summary

This conference summarized microRNA (miRNA) applications in human disease and development. Experts discussed miRNA diagnostics, therapeutics, and mechanistic studies in cancer and neurological conditions.

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Area of Science:

Biochemistry and Molecular Biology
Genetics and Genomics
Translational Medicine

Background:

The 8th Cambridge Health Institute conference convened experts to discuss microRNA (miRNA) research.
Focus areas included the role of miRNAs in human disease pathogenesis and developmental processes.

Framework:

Presentations covered mechanistic studies of miRNA involvement in cancer, cardiovascular disease, and neurodegenerative disorders.
Discussions explored the potential of miRNA-based diagnostic tools and therapeutic strategies.

Implementation:

The conference featured industry-sponsored sessions highlighting cutting-edge miRNA technologies.
Knowledge exchange facilitated advancements in miRNA research and clinical translation.

Implications:

The findings underscore the significant potential of miRNAs as biomarkers and therapeutic targets.
Continued research and technological development are crucial for realizing the full clinical impact of miRNAs.