Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hippocampal Hbα deficiency induces neuronal apoptosis by promoting the accumulation of AGEs.

European journal of pharmacology·2026
Same author

Intramolecular charge transfer endows near-infrared mitochondrial targeted photosensitizers with enhanced photodynamic therapy.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026
Same author

Size switchable nanomodulator achieving ratio-precise dual-drug codelivery for synergistic glutamine metabolism modulation in pancreatic cancer.

Biomaterials·2026
Same author

Online antibiotic purchase in mainland China: A cross-sectional Simulated Patient study.

Public health·2026
Same author

Curcumin and its nano formulation inhibit proliferation and FGF21 expression in esophageal squamous cell carcinoma.

Biochemical and biophysical research communications·2026
Same author

Red Emissive Carbon Dots Photosensitizers for Plant Protection: Highly Effective and Plant-Safe Photodynamic Inactivation of <i>Botrytis cinerea</i>.

Journal of agricultural and food chemistry·2026

Related Experiment Video

Updated: May 20, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Hotspot oncomutations: implications for personalized cancer treatment.

Meagan B Myers1, Yiying Wang, Karen L McKim

  • 1Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA. meagan.myers@fda.hhs.gov

Expert Review of Molecular Diagnostics
|August 1, 2012
PubMed
Summary

Specific tumor mutations like KRAS, BRAF, EGFR, and PIK3CA impact cancer therapy response. Considering minor tumor subpopulations is crucial for improving personalized cancer treatment strategies and overcoming resistance.

More Related Videos

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
10:23

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment

Published on: December 1, 2023

Related Experiment Videos

Last Updated: May 20, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
10:23

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment

Published on: December 1, 2023

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Identifying specific tumor mutations (KRAS, BRAF, EGFR, PIK3CA) is key for predicting patient response to targeted cancer therapies.
  • Existing literature presents nuanced and sometimes contradictory findings regarding the predictive and prognostic significance of these mutations.
  • Variations in mutation detection sensitivity across studies may contribute to the lack of clarity in current research.

Purpose of the Study:

  • To explore the impact of specific tumor mutations on patient response to targeted cancer therapies.
  • To highlight the prognostic significance of tumor mutations independent of treatment.
  • To address the challenges posed by contradictory findings and varying methodologies in the field.

Main Methods:

  • Review of recent research findings on KRAS, BRAF, EGFR, and PIK3CA mutations.
  • Analysis of the predictive and prognostic power of these mutations in different patient populations.
  • Consideration of the role of minor tumor subpopulations in treatment outcomes.

Main Results:

  • Predominant tumor mutations (KRAS, BRAF, EGFR, PIK3CA) show predictive value for therapy response and prognostic significance.
  • Minor tumor subpopulations may lead to inaccurate patient stratification and treatment resistance.
  • Relapse following targeted therapies can be linked to the presence of these subpopulations.

Conclusions:

  • Understanding tumor mutation impact is vital for personalized cancer treatment.
  • Addressing methodological variations in mutation detection is necessary for clearer insights.
  • Incorporating the analysis of minor tumor subpopulations is essential for refining treatment strategies and improving patient outcomes.