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COPD: Pathogenesis and Clinical Features

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Updated: May 20, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
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Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Sarcoidosis - a clinically orientated review.

Mahmoud Dastoori1, Stefano Fedele, Jair C Leao

  • 1Department of Maxillofacial Medicine and Surgery, Oral Medicine unit, UCL Eastman Dental Institute, London WC1X 8LD, UK.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|August 1, 2012
PubMed
Summary

Sarcoidosis is a multisystem inflammatory disease of unknown origin. Diagnosis requires granulomas, but treatment and prognosis vary, impacting vital organs.

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Last Updated: May 20, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Area of Science:

  • Immunology
  • Pulmonology
  • Dermatology

Background:

  • Sarcoidosis is a multisystem disease with an unknown etiology.
  • It affects individuals of all races, sexes, and ages, predominantly young and middle-aged adults.
  • Commonly presents with bilateral hilar lymphadenopathy, pulmonary infiltration, skin, and ocular lesions, but can affect other organs.

Purpose of the Study:

  • To summarize the key aspects of sarcoidosis, including its presentation, diagnosis, and management.
  • To highlight the diagnostic criteria and the importance of excluding other causes of granulomas.
  • To discuss the current limitations in treatment guidelines and prognostic factors.

Main Methods:

  • Review of clinical and radiological findings.
  • Histopathological confirmation through non-caseating epithelioid cell granulomas.
  • Exclusion of other granulomatous diseases.

Main Results:

  • Diagnosis is confirmed by clinical, radiological, and histopathological evidence of non-caseating granulomas.
  • Corticosteroids are the primary treatment, but evidence for optimal use is limited.
  • Prognosis varies significantly, ranging from self-limiting to progressive fibrosis.

Conclusions:

  • Sarcoidosis is a complex disease requiring careful diagnosis and management.
  • Further research is needed to establish evidence-based treatment protocols.
  • Understanding prognostic indicators is crucial for patient care.