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Updated: May 20, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Concepts in advanced renal carcinoma
1Medical Oncology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, C434 Med Inn, SPC 5843, Ann Arbor, MI 48109-5843, USA. pesper@umich.edu
Objectives:
Treatment options for advanced renal cell carcinoma have increased dramatically over the past 6 years as a result of improved understanding of the biology of renal cancer and the development of therapies to target pathways relevant to tumor progression.
Data Sources:
Research-based articles.
Conclusion:
New therapies to treat advanced renal cell cancer results in a need for evidence-based decision making when discussing treatment choices.
Implications For Nursing Practice:
Knowledge of therapeutic strategies, their proposed mechanism of action, potential adverse events, and management strategies provides nurses with a foundation to provide appropriate patient education and effective management of treatment-related side effects, assisting patients to maximize clinical outcomes.
Insights
Advanced renal cell carcinoma treatments have expanded, necessitating evidence-based decisions. Nurses need to understand new therapies for effective patient education and side effect management to improve outcomes.
Area of Science:
- Oncology
- Translational Medicine
Background:
- Advanced renal cell carcinoma (RCC) treatment landscape has evolved significantly.
- Improved understanding of RCC biology drives novel therapeutic development.
Purpose of the Study:
- To review current treatment options for advanced RCC.
- To highlight the need for evidence-based decision-making in advanced RCC therapy.
Main Methods:
- Systematic review of research-based articles.
- Analysis of therapeutic strategies and their mechanisms of action.
Main Results:
- Numerous new therapies targeting RCC progression pathways are now available.
- Effective management of treatment-related side effects is crucial.
Conclusions:
- The expansion of advanced RCC therapies requires informed, evidence-based patient care discussions.
- Nurses require comprehensive knowledge of new treatments, including adverse event management, to optimize patient outcomes.
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