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Related Experiment Video

Updated: May 20, 2026

An All-on-chip Method for Rapid Neutrophil Chemotaxis Analysis Directly from a Drop of Blood
07:21

An All-on-chip Method for Rapid Neutrophil Chemotaxis Analysis Directly from a Drop of Blood

Published on: June 23, 2017

On-chip open microfluidic devices for chemotaxis studies.

Gus A Wright1, Lino Costa, Alexander Terekhov

  • 1Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA.

Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
|August 1, 2012
PubMed
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Researchers developed novel microfluidic devices for precise cell migration control. These "open" chemotaxis systems create passive chemoattractant gradients, enabling new possibilities for in vivo drug delivery and cell analysis.

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Microfluidics

Background:

  • Microfluidic devices offer precise control over cellular microenvironments.
  • Chemoattractant gradients are crucial for studying cell migration.

Purpose of the Study:

  • To design and fabricate novel microfluidic devices for controlled cell migration.
  • To develop open chemotaxis devices for passive chemoattractant gradient generation.
  • To explore the potential of these devices for intravital applications.

Main Methods:

  • Laser machining of micro and nanofluidic channels in fused silica.
  • Design of open chemotaxis devices for unobstructed cell migration.
  • Utilizing cover slip microfluidics for high-throughput assays.

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A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients

Published on: April 19, 2010

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Last Updated: May 20, 2026

An All-on-chip Method for Rapid Neutrophil Chemotaxis Analysis Directly from a Drop of Blood
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An All-on-chip Method for Rapid Neutrophil Chemotaxis Analysis Directly from a Drop of Blood

Published on: June 23, 2017

A Customizable Chamber for Measuring Cell Migration
07:33

A Customizable Chamber for Measuring Cell Migration

Published on: March 12, 2017

A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients
09:28

A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients

Published on: April 19, 2010

  • Demonstration of cell recruitment into cover slip ports.

    • Main Results:

    • Successfully created microfluidic devices with integrated micro/nanofluidic channels.
    • Developed open chemotaxis devices generating passive chemoattractant gradients.
    • Achieved efficient cell loading and strategic placement.
    • Demonstrated cell recruitment into cover slip ports eliciting gradients.

    Conclusions:

    • Novel microfluidic devices provide enhanced control over cell migration and chemoattractant gradients.
    • Open chemotaxis systems and cover slip microfluidics are suitable for high-throughput assays.
    • Intravital cover slip fluidics show promise for in vivo drug delivery and cell analysis under microscopic observation.